MuriPhys supports preclinical ocular research with study-specific delivery, imaging and functional assessments. The current service range includes research relevant to retinal degeneration, glaucoma and corneal disease.
Connect the ocular model, anatomical target and endpoints with the therapeutic question. Our scientists help define the methods and interpretation for the study.
Eye Diseases We Specialize In:
Retinitis Pigmentosa (RP)
Retinitis Pigmentosa, a genetic disorder causing progressive photoreceptor degeneration, demands precise intervention at the retinal level. MuriPhys employs adeno-associated virus (AAV) vectors for gene therapy delivery, alongside intravitreal (IVT) injections to achieve localized drug distribution. Our optodrum and OCT imaging tools track visual function and retinal integrity, providing comprehensive endpoints for therapeutic development.
Glaucoma research can incorporate intravitreal or intracameral delivery with structural and functional readouts. OCT can assess ocular structure. Pressure measurements and visual-function endpoints require methods selected for their specific purpose.
Fuchs Endothelial Corneal Dystrophy (FECD)
FECD, driven by corneal endothelial cell degeneration, presents unique challenges in therapy development. MuriPhys utilizes intracameral injections and topical drug delivery to target the corneal endothelium directly. Imaging technologies, including OCT, track corneal clarity and thickness, while ERG and optodrum tests assess visual function, providing a complete picture of disease progression and therapeutic efficacy. Read More.
Why MuriPhys for Eye Disease Research?
- Ocular Delivery: Intravitreal, intracameral and other study-appropriate administration routes are selected for the intended anatomical target and test article.
- Advanced Imaging and Functional Testing: OCT, ERG, and optodrum technologies provide non-invasive insights into retinal health, corneal structure, and overall visual function, enhancing data quality and reliability.
- Disease Models: Discuss the specific ocular condition, model readiness, therapeutic modality and endpoints before defining the study.
- Customized Study Designs: MuriPhys tailors every study to reflect the unique pathophysiology of each eye disease, supporting your research achieves the depth and specificity required for successful translation to the clinic.