Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive neurodegenerative disorder that primarily affects motor neurons, the nerve cells responsible for controlling voluntary muscles. As these neurons degenerate and die, the brain loses its ability to initiate and control muscle movement, leading to severe physical disabilities.
Given the pronounced motor neuron degeneration in ALS scientists often focus their research on the motor cortex and spinal cord. MuriPhys specializes in intraparenchymal (IPa) drug product delivery to the cerebral cortex and intracerebroventricular (ICV), intrathecal (IT) and intra cisterna magna (ICM) delivery to target the spinal cord and allow broader spread of drug products in the CNS.
ALS is characterized by, muscle atrophy, gait abnormalities, coordination problems and tremors. To complement our CNS delivery we offer behavioral tests and in vivo electrophysiology that assess selected disease-relevant features, including:
