Huntington’s disease is a genetic neurodegenerative disorder associated with a CAG repeat expansion in the HTT gene, which encodes huntingtin. Preclinical research can examine neuronal changes and motor, cognitive and behavioral features in an appropriate model.
Given the involvement of the striatum and cortex in the pathophysiology of Huntington’s disease scientists often focus their research on rescuing the degeneration of medium spiny neurons – the most affected neurons in the striatum. To this end, MuriPhys offers a precise and reproducible intraparenchymal (IPa) drug product delivery into the striatum and thalamus.
Huntington’s disease is characterized by motor, cognitive and psychiatric symptoms.
To complement our CNS delivery, we offer behavioral tests that assess selected disease-relevant features, including:
