Neuropathic pain is a complex, debilitating condition arising from nerve damage or dysfunction. It affects millions globally, often resisting conventional treatments. At MuriPhys, we specialize in advanced preclinical models that dissect the underlying mechanisms of neuropathic pain, paving the way for innovative and effective therapeutics.
Our specialized platforms integrate precision drug delivery, comprehensive behavioral assessments, and electrophysiological analysis, providing a robust foundation for the development of next-generation pain management solutions.
Neuropathic Pain Research Focus Areas:
Peripheral neuropathic pain studies can consider IPa, IT, IV or other appropriate routes according to the anatomical target and compound. Plantar, von Frey and dynamic weight-bearing assessments can characterize selected responses, with electrophysiology included when appropriate.
Central Neuropathic Pain
Damage to the central nervous system (CNS) from conditions such as stroke or spinal cord injury often results in central neuropathic pain. MuriPhys leverages intracerebroventricular (ICV) and intraparenchymal drug delivery to target affected brain and spinal regions. Behavioral tests assess thermal hyperalgesia and spontaneous pain responses, while EEG and EMG recordings provide critical insights into CNS plasticity and maladaptive pain circuits.
Chemotherapy-Induced Neuropathy
Chemotherapy agents frequently cause nerve damage, leading to long-term pain and sensory deficits. MuriPhys employs systemic and CNS-targeted delivery methods to evaluate neuroprotective compounds. Behavioral assays such as gait analysis and cold plate tests capture the impact of chemotherapy on nerve function, while electrophysiology measures alterations in nerve conduction and synaptic integrity.
Why MuriPhys for Neuropathic Pain Research?
- Drug Delivery: The route and anatomical target are selected for the study. IPa, IT and ICV have distinct delivery locations and distribution characteristics.
- Pain Modeling: Select endpoints such as mechanical sensitivity or thermal response that address defined features of the neuropathic-pain model.
- Electrophysiological Expertise: EEG, EMG, and nerve conduction studies reveal critical biomarkers for neuropathic pain, offering valuable insights into disease mechanisms and therapeutic efficacy.
- Customized Research Programs: MuriPhys designs tailored neuropathic pain models that reflect the pathophysiology of diverse pain conditions, supporting translational relevance and clinical impact.
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