Oncology models play a critical role in preclinical development by enabling researchers to evaluate the efficacy, safety, and pharmacokinetics of investigational therapies in biologically relevant systems before entering clinical trials. These models, ranging from cell line-derived xenografts (CDX) and patient-derived xenografts (PDX) to orthotopic and metastatic tumor models, provide essential insights into tumor growth dynamics, therapeutic response, and resistance mechanisms.
MuriPhys supports oncology studies with animal handling, in vivo imaging, drug delivery, serial tumor measurements, IV/IM/SC dosing, biodistribution and histological analyses. These methods are coordinated around the selected model, hypothesis and endpoints.
[if!supportLists]· Xenograft models – Human tumor cell lines implanted in immunodeficient mice.
[if!supportLists]· Patient-derived xenografts (PDX) – Tumors from patient biopsies implanted in mice for more clinical relevance.
[if!supportLists]· Syngeneic models – Murine tumor models in immunocompetent mice for immuno-oncology studies.
[if!supportLists]· Genetically engineered mouse models (GEMMs) – Tumor development driven by specific oncogenes.
[if!supportLists]· Metastasis models – Evaluating therapies targeting tumor spread
Advanced Drug Administration & Serial Injections
We specialize in the following routes of administration:
Intravenous (IV), Intramuscular (IM), Subcutaneous (SC), Intrathecal (IT), Intra Peritoneal (IP), Oral Gavage (PO), Topical, Slow-infusion and Continuous Infusions – supporting accurate systemic or localized therapeutic exposure.
Serial Injections – Enabling longitudinal drug administration studies to monitor treatment effects over time.
Quality Control: Mycoplasma Testing
Cell-line quality control includes mycoplasma testing to identify contamination. The testing plan, cell identity checks and acceptance criteria are defined for the study and documented with the work.
At MuriPhys, we are dedicated to accelerating oncology drug discovery with specialized preclinical solutions. Contact us today to discuss how we can support your oncology research!
Discuss the tumor model, treatment strategy, readouts and study stage with our oncology team. We will work with you to define the methods, controls, deliverables, timing and budget.