MuriPhys supports preclinical pain research through CNS and systemic delivery, behavioral assays and functional readouts. Methods are selected for the model and the type of evoked, spontaneous or functional response under study.
MuriPhys partners with researchers to explore breakthrough therapies that target the neurological and physiological roots of pain, driving innovation toward long-lasting relief.
Pain Disorders We Specialize In:
Neuropathic-pain research can connect IPa, ICV or IT administration with plantar testing, conditioned-place-preference studies or other suitable assessments. The anatomical target, model and interpretation are specified for the study. Neuropathic Pain Read More.
Inflammatory Pain
Inflammatory pain results from tissue damage and immune response activation. MuriPhys utilizes systemic and CNS delivery approaches to evaluate anti-inflammatory compounds, with oral gavage (OG), intraperitoneal (IP), and subcutaneous (SC) delivery options. Behavioral models, including open field and rotarod tests, track pain-induced changes in mobility and behavior, supporting comprehensive assessment of therapeutic efficacy. Read More.
Visceral Pain
Visceral pain, often associated with internal organ dysfunction, presents unique challenges for therapeutic intervention. MuriPhys employs IPa and ICV drug delivery to target central pain processing centers, while behavioral assays monitor abdominal writhing and referred pain responses. Electrophysiological studies further elucidate pain signal transmission and modulation, supporting the development of targeted analgesics. Read More.
Why MuriPhys for Pain Research?
- Drug Delivery: Connect CNS or systemic administration with the anatomical target, test article and study design.
- Behavioral Assays: Thermal sensitivity, conditioned responses and other selected assays assess defined features of the pain model.
- Electrophysiology: EEG and EMG can add brain and neuromuscular readouts to selected pain studies. Recording conditions and interpretation are defined for the study.
- Tailored Models for Translational Research: MuriPhys specializes in pain models that reflect the multifaceted nature of pain disorders, supporting that therapeutic evaluations align with clinical realities.
Partner with MuriPhys to drive innovation in pain research, where precision and discovery pave the way to relief.