Our team connects rodent-model selection, CNS delivery and appropriate assays to test the therapeutic hypothesis. Models, controls and endpoints are defined around the evidence needed for the next decision.
Work directly with our scientists to define a practical scope, method readiness, timing and the interpretation of the proposed research.
We specialize in neurodegenerative and neurodevelopmental disorders such as Huntington’s Disease, Ataxia, and Rett Syndrome, and have deep knowledge in rodent models of these diseases including (not limited to) the following 6 mouse models:
- Tg/Tg
- Atxn1−/−
- BACHD
- YAC128
- FXNYG8Pook/800J
- B6.129P2(C)-Mecp2tm1.1Bird/J
With our expertise, we can successfully deliver various classes of drug candidates and their associated delivery vehicles:
Drug Candidate Classes:
- DNA
- RNA
- Protein
- Small molecules
Delivery Vehicles:
- AAV (Adeno-Associated Virus)
- Lentivirus
- LNP (Lipid Nanoparticles)
Delivery Routes:
- Intraparenchymal
- Intracerebroventricular
- Cisterna Magna
- Intrathecal
- Cannula implants
- Osmotic pumps implants
Neurostar robotic stereotaxy supports micrometer-scale instrument positioning. Anatomical targeting and variability are assessed with study-specific planning and quality controls.
Neurobiology Assays and Behavioral Studies
Additionally, we provide comprehensive behavioral assays to assess neurological function, including:
- Rotarod
- Noldus Catwalk
- Analysis with Treadmill
- Forced Treadmill
- Grip Strength
- Shuttle Box
- O Maze
- Social Behavior
- Plantar Test
Discuss the model, delivery method and readouts with our scientists to design a study that tests the therapeutic hypothesis.