MuriPhys supports rare CNS research by connecting targeted delivery, behavioral assays and electrophysiology. Select the model, anatomical target and readouts around the disease mechanism and the question the study needs to answer.
Work directly with our scientific team to define the model, methods and evidence needed for the next decision.
Disorders We Specialize In:
Huntington’s Disease
MuriPhys provides specialized tools to investigate the progressive neuronal degeneration characteristic of Huntington’s. Our intraparenchymal (IPa) drug delivery directly targets the striatum and cortex, key regions affected by the disease. Complementing this, we offer behavioral assessments such as rotarod, balance beam, and Y-maze, alongside electrophysiological studies (EEG, EMG) to track disease markers and therapeutic efficacy at every stage. Read More.
Ataxia
Ataxia research benefits from MuriPhys’ targeted delivery to the cerebellar cortex and deep nuclei. Our array of behavioral tests assesses gait, balance, and motor coordination, while electrophysiological recordings track cerebellar activity and disease evolution. Read More.
Parkinson’s disease research can combine intraparenchymal delivery to the substantia nigra with study-appropriate ICV or IT approaches. Behavioral assays assess selected motor features, while EEG and EMG can provide relevant brain and neuromuscular readouts. Parkinson’s Disease Read More.
ALS research can incorporate CNS delivery, including IPa and ICV approaches, alongside motor and functional assessments. Open-field testing and other model-appropriate assays can characterize activity and motor changes. OCT is an ocular imaging option when the study includes an appropriate eye-related question. Amyotrophic Lateral Sclerosis (ALS) Read More.
Dementias
From Alzheimer’s to Lewy Body and Frontotemporal Dementia, MuriPhys provides comprehensive tools to dissect the complexities of cognitive decline. Our drug delivery platforms span intraparenchymal, ICV, and IT routes, facilitating localized and systemic targeting. Behavioral assays explore memory and learning, while EEG recordings highlight neuronal dysfunction, offering crucial biomarkers for early detection and progression tracking. Read More.
Rett syndrome research can combine IPa, ICV or IT delivery with model-specific functional measurements. Rotarod and open-field tests can assess motor features. EEG can characterize seizure-related brain activity, while EMG can assess neuromuscular function where relevant. Rett Syndrome Read More.
Fragile X Syndrome
Fragile X, the leading inherited cause of intellectual disability, requires specialized models that capture both cognitive and behavioral symptoms. MuriPhys’ CNS and systemic delivery methods, from IPa to ICV and IT, facilitate targeted treatment evaluations. Our behavioral tests encompass learning, social interaction, and sensory processing assessments, while electrophysiology provides insights into neural excitability and synaptic dysfunction, supporting a holistic approach to drug development.
Angelman Syndrome
Characterized by severe developmental delays, motor dysfunction, and epilepsy, Angelman Syndrome benefits from MuriPhys’ advanced delivery techniques. Our team leverages intraparenchymal and systemic methods to precisely target key brain regions. In addition to rotarod and Y-maze assays, optodrum and OCT imaging capture motor and vision-related deficits. EEG monitoring further tracks seizure progression, supporting a complete picture of disease evolution.
Tourette syndrome research can combine IPa or ICV administration with model-appropriate behavioral and EEG assessments. Define which tic-related or motor features are relevant to the selected model and how treatment responses will be interpreted.
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Why MuriPhys for Rare CNS Disorders?
- Targeted Delivery: Select the administration route, anatomical target and test-article conditions for the study, then assess delivery with appropriate controls and readouts. Tailored Delivery Systems:
- Behavioral Assays: Select social, cognitive or motor assessments that address defined features of the chosen model.
- Electrophysiology: Plan EEG, EMG or other appropriate recordings around the functional question, controls and analysis.
- Comprehensive Approach: Rare CNS disorders require nuanced, multi-faceted strategies. MuriPhys customizes every aspect of the study to align with the unique needs of each condition, driving deeper understanding and faster breakthroughs.